Mild to moderate hypertension and also in enhancing the impact of other antihypertensive agents. Diuretics relieve pulmonary congestion and peripheral oedema. These agents are valuable in decreasing volume more than load and relieve orthopnea and paroxysmal nocturnal dyspnoea [19] in CCF and acute left ventricular failure. They reduce plasma volume and subsequently venous return towards the heart. This decreases the cardiac operate load, oxygen demand and plasma volume as well as decreases blood stress. Thusna mmol/l 113.03 two.16 191.052.09 129.402. total urine Vol (ml/kg b.wt/5 h) 13.45.02 22.23.01 15.20. K mmol/l 51.09 1.51 87.811.60 64.131. Cl mmol/l 82.95 1.42 129.061.67 94.42 1.73 109.441.20 121.392.0017.41.02 20.46.164.992.00 184.532.77.932.67 85.111.[Table/Fig1]: Impact of alcoholic extract of roots of Cissampelos pareira on urine volume and electrolyte concentration in hydrated rat model in albino rats Values expressed as mean S.E.M.,n=6, Significance at p0.05, p0.01, p0.001, Compared with control group (A single Way ANOVA followed by Dunnetts `t’ test).Journal of Clinical and Diagnostic Study. 2014 May, Vol8(5): HC01HCwww.jcdr.netSuresh Babu Sayana et al., Evaluation of Diuretic Activity of Alcoholic Extract of Roots of Cissampelos Pareira in Albino Ratssaponins, organic acids [1,17], steroids, carbohydrates, tannins, phenolic compounds, terpenoids [22], alkaloids [23], glycosides [24], sterols [25], sesquiterpenes aminoacids, carotinoids [26] in unique plant extracts.1-Hydroxyhept-6-yn-3-one Formula Alcoholic extract of roots of Cissampelos pareira was identified with the majority of these plant phytochemical substances described above.1240587-88-5 Chemical name Therefore it may be reported that the observed diuretic activity is as a consequence of these above phytoconstituents.PMID:24367939 CONCLUSIONResults showed that single dose administration of alcoholic extract of roots of Cissampelos pareira as one hundred,200 and 400 mg/Kg and typical Furosemide (10 mg/kg) have increased the urinary output along with a rise in concentration of Sodium, Potassium and Chloride ions in urine. Alcoholic extract of roots of Cissampelos pareira mg/Kg produced a greater diuretic activity that is comparable to that of typical Furosemide (ten mg/kg). In classic medicine the plant is used for its diuretic activity. Ours scientific study come up with identification of a lot of phytoconstituents reported earlier for this diuretic impact in our alcoholic extract of roots of Cissampelos pareira. Hence our study supports and justifies the rationale behind the folklore use of roots of C.pareira for its diuretic activity.[Table/Fig2]: Effect of alcoholic extract of roots of c. pareira on urinary sodium, pot assium, chloride (mmol/l) ions concentration in hydrated rat model in albino ratsACkNOwLEDGEMENTSThe authors are very much grateful to Dr. S.M.Shanth Kumar Ex Principal, V.L. College of Pharmacy and Dr. V.Hemanth Kumar Principal V.L. College of Pharmacy, Raichur, Karnataka for supplying the laboratory facilities to carry out the part of this Ph.D experimental function and Dr. Shashidhar Basagoudar, Assistant Professor, Division of P SM, RIMS, Raichur, Karnataka, India for assisting in the preparation of this manuscript.
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