Ed with nalmefene, compound 5 possessed much less inhibitory potency against the P
Ed with nalmefene, compound five possessed significantly less inhibitory potency against the P450s studied (i.e., CYP3A4, -2B6, -2C9, -2C19, and -2D6). A feasible exception was CYP2C19,Ethanol Self-Administration StudiesP-rats have been…